Caloric restriction has been shown to improve healthspan in rodents and non-human primates, but its sustainability for humans is a significant challenge.

“Yeah. Yeah, I think, you know, calorie restriction has been going around for quite a while. I think the issue is most people can't actually sustain... No, I mean I think there's, you bring up a really good point, like there's been a lot, it's like the classical intervention that's been done in rodents, it's been done in non-human primates, and it's been shown to...you know, it does improve health span of those animals that are not humans. And in some cases, they really restrict it, like 30%, like they eat 30% less calories or fewer calories.”