The benefits of metformin can be achieved through intermittent fasting and ketosis without side effects like reduced testosterone, B12 deficiency, or lactic acidosis.

“if you are a human that makes intentional choices with their diet I'm not aware of any benefits to metformin that you cannot achieve through intermittent fasting ketosis you know if we're talking about genetics if we're talking about a CH DAC you know if we're talking about histone deacetylase in habitual the the benefits of metformin on the amp kinase system are generally achievable in a ketogenic state yeah and then you don't have the side effects including lowering testosterone b12 deficiency lactic acidosis”