Bryan Johnson· Author
+ Age mediated the risk posed by PFOA in adolescents; each year increase in age added a 45% increased odds of fatty liver disease for every doubling of PFOA plasma concentration.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
+ Age mediated the risk posed by PFOA in adolescents; each year increase in age added a 45% increased odds of fatty liver disease for every doubling of PFOA plasma concentration.
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+ PFOA showed the highest risk increase for fatty liver disease in adolescents; each doubling of PFOA plasma concentration was associated with a 169% increased odds of fatty liver disease.
+ In one cohort, each doubling of PFHpA was associated with a 73% increased risk of fatty liver disease in adolescents.
Each doubling in PFHxS concentration was associated with a 552% increase in fatty liver disease odds in older adolescents carrying the PNPLA3 GG high-risk phenotype.
+ The high-risk PNPLA3 genotype significantly increased the risk of fatty liver disease with PFAS exposure in adolescents, particularly for PFHxS.