Aging can be defined from a functional perspective, considering changes like frailty across all organ systems, which are important for healthspan and longevity.

“i have developed uh i think a greater appreciation for a functional definition of aging and so i you know as i start to think more and more about translation of interventions that seem to affect the biological aging process um in laboratory animals outside of the laboratory into the clinic you know i spend a lot of time thinking about well what are some of the functional changes that go along with with aging and and we know that across every organ system in the body we see functional declines that go along with aging and so i've started to think more about you know things like frailty uh uh as an important component of defining aging from a biological perspective you know when when we're talking about having an impact on health and longevity”