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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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The challenges of defining aging — Whalespan

Content›Video›The challenges of defining a…

The challenges of defining aging

Peter Attia12m · 2021-09-15

Claims Made

15

Claims Supported

8

Support Rate

53%

Support rate

8 of 15 claims supported

8 supported7 partial / not

Claims from this content

15

✓Well SupportedRapamycin is one of the most effective known cancer-preventive agents in mice, and lifespan extension in mice may largely reflect a delay of multiple forms of cancer.◐Partially SupportedThe hallmarks of aging include mitochondrial dysfunction, loss of stem cells, senescence, nutrient deregulation, and telomere shortening.◐Partially SupportedFrailty is a key outward expression of biological aging at the organismal level.◐Partially SupportedAging can be defined from a molecular perspective, focusing on damage accumulation and its consequences, such as mitochondrial dysfunction and telomere shortening.Partially Supported

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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◐

A ketogenic diet is likely the best treatment for type 2 diabetes because it is a carbohydrate intolerance disorder.

◐Partially SupportedAn intervention that affects biological aging may not be effective once a disease pathology has progressed to a point where its mechanisms differ from aging biology.

◐Partially SupportedAging can be defined from a functional perspective, considering changes like frailty across all organ systems, which are important for healthspan and longevity.

◐Partially SupportedThe molecular pathology of some age-related diseases may diverge from normative aging biology.

✕Not SupportedA ketogenic diet is not necessarily required for the prevention of diabetes.

◐Partially SupportedCardiovascular disease and dementia are functional forms of decline with underlying cellular components that contribute to aging.

◐Partially SupportedFunctional declines occur in every organ and tissue during aging, often before age-related disease is diagnosed.

◐Partially SupportedThe optimal nutritional strategy to prevent a condition may differ from the optimal nutritional strategy to treat the disease once it is present.

◐Partially SupportedA ketogenic diet can help individuals with type 2 diabetes recover by eliminating carbohydrates.

◐Partially SupportedIndividuals with type 2 diabetes on a ketogenic diet may resume some carbohydrate consumption if other factors like exercise are modified.

◐Partially SupportedFunctional declines that precede overt disease are as important as disease itself for quality of life as people age.