Andrew Huberman· PhD
why 1000 fold increases in GLP1 are requisite for significant weight loss
Loading…
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
why 1000 fold increases in GLP1 are requisite for significant weight loss
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
These These gp1 agonists are really a pharmacologic effect effect that only happens with drugs so you get a thousand to 10,000 fold higher concentrations of these drugs in your blood than uh the natural hormone
So Zachary Knight came on here and beautifully explained how the drugs that increase GLP-1 increase it many thousand fold above natural levels to have it exert its effect of reducing hunger.