Weight loss with GLP-1 agonists is achieved by consuming fewer calories than expended, aligning with the laws of thermodynamics.

“Well and if nothing else those drugs prove that one of the main reasons perhaps the main reason why so many people are overweight or obese is that they eat more than they burn.”

“We now know thanks to GLPs, if you eat less than you burn, you lose weight.”

“glp1 limit food intake energy expenditure”