The primary question regarding additional indications for GLP-1 agonists is whether benefits exceed those from weight reduction and improved metabolic health.

“And they may have other benefits, too. You know, we haven't fully figured out.”

“the jugular question with all of these indications is going to be is there a benefit of the drug above and beyond the two things that we know it's doing which is reducing weight and improving metabolic health and glycemic control”

“I think the other thing that I really want to focus on today is understanding the other health benefits associated with it so if anybody's you know scrolling through their Google feed it's you almost can't go a day certainly not a week without something popping up as yet another benefit of this class of drug so it's like uh oh it's just been discovered that you know not only are glp1 uh agonists and it usually won't say that it'll say not only is OIC good for weight loss but it's also good for treating your sleep apnea or it's true it's you know it's good for preventing Dementia or all these other things”

“Even all of that could simply be an outcome of improving metabolic health because back to the origins or the beginning of our conversation because metabolic health is so foundational to chronic disease. All of this could just be a consequence of improving metabolic health.”

“Now people are saying, well, it's a blood pressure drug, it's an Alzheimer's drug, it's a fertility drug.”

“And you have to wonder like is is this a is there a direct effect of you know agonizing these GLP-1 receptors on different tissues or is this just an indirect effect of weight loss and improved metabolic health?”