The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
I think the glp-1 agonists are such a great example yeah yeah um you know I don't think anybody fully understands exactly how they're working but it's hard to argue that they're impacting that the glp-1 analog is is having a central impact
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
it's hard to argue that they're impacting that the glp-1 analog is is having a central impact it's doing something in the brain that is leading to a reduction of appetite we believe that yeah yeah and I think the mouse data point to different areas of the hypothalamus that are related to satiety
my understanding is that glp1 that that not that's injected but that one um makes naturally is acting on both the brain and the gut to increase satiety so it is acting on the brain no argument but the primary action is on the gut glp1 decreases the rate of gastric emptying that is its primary driver yes it does affect the brain I'm not arguing that it does but the primary effect is to reduce the rate of gastric emptying so you stay Fuller longer because the food doesn't move through the stomach and the intestine
and I think the mouse data point to different areas of the hypothalamus that are related to satiety that that say it's at least possible
I think the glp-1 agonists are such a great example yeah yeah um you know I don't think anybody fully understands exactly how they're working but it's hard to argue that they're impacting that the glp-1 analog is is having a central impact it's doing something in the brain that is leading to a reduction of appetite we believe that
Now the combination of those two is powerful where you have the I'm full signal here and I have a lot of stuff in my stomach here resulting in a person who has a much better control over their appetite. I guess to say that a polite way or to say that another way they just don't have as much of an interest in eating.
within the intestines GLP-1 will act to delay gastric emptying and slow paristalsis. So that has the effect of a person eating and having that bulk sit in their stomach much longer which is going to generally discourage them from wanting to eat more. At the same time, it's going to take a lot longer to get through the intestines.