The body's homeostatic systems are strongly regulated and difficult to override, requiring significant peptide hormone increases for long-lasting weight changes.

“it's hard to outsmart the system right because you know these you know these neurons are making predictions based on the sight and smell of food but then the gut is doing its own thing it's calculating it separately and relaying that information so at every step there are these checks basically they are just confirming that what you thought happened the first time is actually what's really going on and so and it's which makes sense because it's so important for survival these homeostatic systems are the product of you know so much natural selection which I think at least partially explains why thousandfold increases in peptide hormones like glp1 are required to see significant long- lasting changes in weight”