Peter Attia· MD
if you knock serotonin out of the epithelium then there's problems signaling back to the brain and the peristalsis reflex is impaired it's not stopped but it's impaired because the enteroendocrine cells in the gut can trigger peristaltic waves that are propulsive but if you lose that then in order to trigger it you have to press harder and harder and dilate the gut and get the nervous system to do this directly