Peter Attia· MD
what are the effects of ssris outside of the cns do they impact the gut specifically yes they tend to cause nausea by enhancing the ability of serotonin to talk back to the brain to trigger nausea drugs that are used in cancer chemotherapy also trigger the release of serotonin within the gut and trigger that reflex same one the ssris also first make the gut go a little bit faster but then when the gut keeps doing that the receptors that is the molecules upon which serotonin acts desensitize one way they do that is to internalize and so they can actually block the effect of serotonin in transit so in terms of motility they can make the gut go faster and ultimately they stop the gut and give rise to long-term constipation and have to be stopped