If tight junctions in the gut lining open, protein can enter the GI tract, leading to exudative enteropathy and severe edema.

“and worse than that protein from the body it turns out that underneath the lining of the gut capillaries are very permeable and there's a lot of protein in the lymph the fluid underneath the lining and so if you open the lining of the gut that protein gets into the gi tract and that's a disease called exudative enteropathy”