Maintaining colon hypoxia requires sufficient mitochondrial substrates in colonic epithelial cells.

“and basically having enough of that energy produced through mitochondrial oxidation is really important for maintaining hypoxia in the gut and hypoxia normally isn't a good thing but in your in in your colon where you want an anaerobic environment you want to keep that very low in oxygen you need basically enough basically enough substrates for your mitochondria in your colonic epithelial cells to maintain that because the mitochondrial oxidation utilizes oxygen coming in from the bloodstream”