The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
For instance, the neuromodulator dopamine can be synthesized by or from bacillus and serratia. ... these particular gut microbiota can create dopamine in our gut that can get into our bloodstream and can generally change our baseline levels of dopamine within the brain and other areas of the body.
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So we've got gut microbiota that can literally be turned into dopamine and raise our baseline levels of dopamine.
for example the gut bacteria known as lactobacillus produces the neurotransmitter Gaba the gut bacteria known as interlocus can produce serotonin and the gut bacteria basilis can produce dopamine