Peter Attia· MD
it gave us a lot of confidence frankly it gave the feel a lot of confidence that integrated measure of reverse cholesterol transport is actually relevant to atherosclerto cardiovascular disease at least in mice
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
it gave us a lot of confidence frankly it gave the feel a lot of confidence that integrated measure of reverse cholesterol transport is actually relevant to atherosclerto cardiovascular disease at least in mice
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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several years ago with this concept of reverse cholesterol transport as a dynamic process we developed an assay in mice that simply speaking involved taking cholesterol-loaded macrophages with labeled cholesterol injecting them into the mice and then following that label all the way through the HDL to the liver to the gut to the feces and we called that integrated reverse cholesterol transport and we showed in a variety of different genetic and pharmacologic approaches that when you tweak that process either up or down it mirrored the effect of that process on atherosclerosis what I'm really trying to say is something that promoted that process and made it more efficient also reduced atherosclerosis something that constipated that process increased atherosclerosis