Nicotine affects acetylcholine receptors, contributing to habit formation through throat relaxation and verbal fluidity, counteracted by its vasoconstrictive properties.

“it doesn't just hit the nicotinic receptors it'll also hit the muscarinic acetylcholine receptors and that's one reason why if you do take nicotine gum or use nicotine gums or pouches what you'll notice is when you don't use it you'll feel as if your throat is a little — mildly irritated and and then you take it and it and it relaxes it interesting and this is one of the more subtle but powerful ways in which it is habit forming is that people feel like they're more verbally fluid they can breathe easier when they're taking nicotine but it's a vasal constrictor so that for those interested in performance enhancing effects — it's run pushing you in the opposite direction”