Phase 1 (0-8 hours after waking) is characterized by elevated norepinephrine, epinephrine, dopamine, cortisol, and body temperature, supporting alertness.

“Phase one, which again, is 0 to 8 hours after waking, has a particular neurochemical signature. Regardless of what you do, the neuromodulators norepinephrine as well as epinephrine, so that's noradrenaline and adrenaline, as well as the neuromodulator dopamine tend to be elevated during that first 0 to 8 hours after waking. There are a number of reasons for this related to the fact that also cortisol is higher in our brain and bloodstream, it's a healthy level of cortisol upon waking, body temperature is increased, et cetera.”