Rhonda Patrick· PhD
It turns out that lactate—a metabolite produced during intense exercise—plays a crucial role. When researchers removed the receptor for lactate, called HCA1, mice no longer experienced the same surge in new brain cells.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
It turns out that lactate—a metabolite produced during intense exercise—plays a crucial role. When researchers removed the receptor for lactate, called HCA1, mice no longer experienced the same surge in new brain cells.
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one of the mechanisms that's thought to underly this is you know the the unique effects of you know vigorous intensity exercise or hit on the brain because of the lactate production so during high-intensity exercise lactate is produced in large amounts as we've talked about about um largely as a byproduct of the metabolic stress you're you're kind of pushing that Anor robic threshold and when you produce lactate it's getting into circulation and it can cross the bloodb brain barrier there are lactate Transporters MCT Transporters on the bloodb brain barrier and it can you know cross the bloodb brain barrier and get into the brain where it then acts as a signal and it triggers a variety of beneficial adaptations