COMT is an enzyme that transfers a methyl group from catecholamines.

“so comy is cacal othl transferase and you know what's astounding is methylation is also called one carbon metabolism carbon and three hydrogens in molecular biology it is it it really is astounding when you when you look at molecules and how very subtle changes dramatically change the impact of that molecule's action in the body so by breaking off a methyl group of carbon and three hydrogens or adding a methyl group you dramatically change the impact of neurotransmitters of of all kinds of things downregulated homoy metabolize other nutrients and and it's a it's a a very simple process a very small process if you will but it has a dramatic impact in the body so cacal othl transferase is transfering a methyl group from the category of neurotransmitters known as catac colomines”