Peter Attia· MD
the body is going to regulate these three enzymes in response to various physiologic circumstances and that's effectively at the cellular level how the body is controlling thyroid function
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
the body is going to regulate these three enzymes in response to various physiologic circumstances and that's effectively at the cellular level how the body is controlling thyroid function
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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D1 and D2 are quite similar in that they both convert T4 into T3 more about that in a moment it's just where they do it that's slightly different D1 is extracellular it's on the cell membrane facing outward whereas D2 is on the membrane of the endoplasmic reticulum and it's facing internal to the cytosol but put that aside for a moment and just keep in mind that D1 and D2 both convert T4 into the active hormone T3