The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
so it's really estrogen through its breaking of the negative feedback mechanism on cortisol that ultimately causes the atrophy of the thymus gland while simultaneously increasing the production of immature white blood cells and if this mechanism gets out of control you essentially get the various hematological cancers leukemias lymphomas right
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people with high estrogen tend to have higher than Baseline than normal Baseline cortisol now the cortisone may be again like I said in the normal range but it may not be it may no longer exhibit a diurnal Rhythm right in which case having let's say higher than normal cortisol still in range but you know according to the PM the PM range to be above range that over time will actually lead to timeic Evolution
so it's really estrogen through its breaking of the negative feedback mechanism on cortisol that ultimately causes the atrophy of the thymus gland while simultaneously increasing the production of immature white blood cells
so people with high estrogen uh tend to have higher than Baseline than normal Baseline cortisol now the cortisol may be again like I said in the normal range but it may not be uh it may no longer exhibit a diurnal Rhythm right in which case having let's say higher than normal cortisol still in range but you know according to the PM the PM range to be above range that over time will actually lead to timeic Evolution