Andrew Huberman· PhD
DHT dihydrotestosterone as I mentioned in the previous episode, has this dramatic role in creating a kind of masculinization of the brain prenatally, it also defines the primary sex characteristic of the growth of the penis, et cetera, and beyond infancy and early childhood and later in life, it has powerful effects in creating balding, in beard growth, et cetera, and it has a much higher affinity for the androgen receptor than does testosterone, so creatine can increase DHT, which means that if you take creatine and you're very DHT-susceptible, then you might experience some hair loss, this has been heavily debated, does creatine cause baldness? It's going to depend, it's going to depend on how much 5-alpha reductase you have and how prone to hair loss you are, some people can take creatine without any problem in terms of hair loss, some people cannot, they start losing their hair to levels that, at least for them, aren't comfortable.