Behaviors or substances that increase dopamine lead to increased neural circuits for frustration, pain, and lack.

“And the way this works is that anytime that we engage in a behavior or we ingest something that increases our levels of dopamine, there is a subsequent increase in the neural circuits that control our sense of frustration, pain, and lack.”

“So this puts you on a very complicated seesaw. It's a very wobbly precarious state to be in.”

“In fact, we can say that the longer it's been since you've indulged in something that you really enjoy or would like, the greater the dopamine you will experience when you finally engage in that behavior or indulge that thing, ingest that thing.”