Individuals with a mutation in the gene encoding 5-alpha reductase experienced incomplete sexual maturation and had similar muscle mass to controls.

“you see mutations in the gene that encodes for five Alpha reductase which is the enzyme that makes DHT and you'll note that certain um pseudo hermaphrodites who don't have DHT will end up you know lesser developed in the masculine Spectrum than a normal functioning human with full DHT production”

“individuals that had a mutation in the gene that encodes for five alpha reductase seem to not undergo full sexual maturation in adolescence and they would end up with shockingly the same amount of muscle mass as like you know their like for example siblings who weren't affected but inhibited uh maturation of uh genitals for example like not full that often end up with like a micro penis that's like where that comes from typically but also no facial hair growth really and no temporal recession is like one of the hallmarks of uh you know the uh they're called pseudoh hermaphrodites which is like I don't know male pseudo hermaphrodites and maybe that's not like a a correct term now but that's what they are in the literature and it is literally these individuals have no inhibition in their capacity to produce testosterone it is all the DHT.”

“So like the only thing like how they developed these drugs was they found that um individuals that had a mutation in the gene that encodes for five alpha reductase seem to not undergo full sexual maturation in adolescence and they would end up with shockingly the same amount of muscle mass as like you know”