Paul Saladino· MD
all of these hormones testosterone estrogen and inhibin produced by the sertoli cells as a result of fsh feedback negatively at different parts of the hypothalamic pituitary gonadal access
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
all of these hormones testosterone estrogen and inhibin produced by the sertoli cells as a result of fsh feedback negatively at different parts of the hypothalamic pituitary gonadal access
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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testosterone levels as they rise will inhibit both the hypothalamus and the pituitary which slows down GnRH and LH and FSH this is actually much more complicated than I've drawn it here and I realize that there's going to be some purist out there who says oh my God you forgot to mention this yeah so it turns out that the hypothalamus does not have an overwhelming number of Androgen receptors so this is not happening directly but rather indirectly