Methylation, involving methyl donors like glycine and methionine, is a key step in estrogen metabolism for excretion.

“and after it goes into after the methyl donor is added then it goes through three is where it needs to be excreted either in the urine and the feces”

“then after the estrogen goes through these three phases or goes through this first phase into these three metabolites then it has to get methylated and for people that don't know what methylation is it's basically well here Paul you give a good explanation of methylation methyl donors or methyl donors or basically B vitamins choline Felipa thiamine Samy and then there are two snips or genes that are major players in this the MTHFR gene and the COMT gene”