Original IVF procedures lacked gonadotropins and required daily hormone measurements and abdominal surgery for egg aspiration.

“I think the oldest IVF babies, we didn't have gonadotropens. We didn't have FSH. um that was you know synthetic or purified and so we couldn't get multiple eggs to grow. So original IVF patients had to go live at their IVF clinic and they had urinary based hormone measurements done every day so they could try to gauge when as estradiol was rising when they were getting closer to ovulation and in those days this is just science they went and they did abdominal surgery to aspirate the egg.”