The WHI study selected an older population to increase the incidence of heart events for sooner detection of differences between hormone users and non-users.

“if they were looking to see the benefit on heart disease what they said was well we're going to take an older population because the incidence of heart events would be greater in that population we would see a difference sooner between the women who are on hormones and those who weren't”

“no it was on sorry into menopause yeah the criteria were based on age so the women were 50 to 79 with a mean age of 63. some of them had gone through menopause in their early to mid 40s some of them had even had hysterectomy with ovaries removed in their 40s or much earlier in life so there was no exclusion on the basis of for example being more than 20 or 30 years past menopause was on the basis of age 50 to 79.”

“and then in the other group The no uterus group they were just given conjugated equin estrogen versus placebo they didn't have to be given the mpa the synthetic estrogen um these women were on average considerably older they were I want to say 7 to 10 years out of menopause at this point”