Bryan Johnson· Author
Elevated IGF-1 feeds back on hypothalamic GHRH. The nighttime GHRH surge that gates SWS may get blunted.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Elevated IGF-1 feeds back on hypothalamic GHRH. The nighttime GHRH surge that gates SWS may get blunted.
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The only trial that measured it: CJC-1295 DAC preserved nocturnal GH pulses but raised basal GH 7.5-fold.
GH-IGF-1 axis also talks to the HPA clock. Tonic elevation can scramble cortisol rhythm. Jet lag, endogenously generated.