Increased SHBG due to hormonal contraception may contribute to low desire in women by binding up circulating testosterone and potentially lowering free testosterone.

“so because you're increasing shbg there's some um thinking that you're binding up the circulating testosterone and you may be lowering free testosterone in those women and that might be another potential contributor low desire”

“what do you do when you make all send all that hormone into someone's body you increase the production of shbg right yep so so you're binding up more of the hormone as well so right you need something well the easiest way to think about it is you need something to carry it around with right and that shpg goes up in other states like pregnancy um and you might ask me like is it the same with viral pills and pregnancy or when you take thyroid hormone any there are other things that make that production of that go up um the data across situations is can like you could say okay it's like around a hundred such with this or is not so clear I think it's best just to say it makes it go up”

“what do you do when you make all send all that hormone to someone's body you increase the production of shpg right”

“And this gets really rough in females because they a lot of them are using things like combined oral contraceptives which crank SHBG through the roof through the liver uh interaction with the oral combined oral contraceptive pills.”