Andrew Huberman· PhD
a late-shifted cortisol pulse, in particular, a 9:00 p.m. or 8:00 p.m. increase in cortisol is one of the consequences, and maybe one of the causes, of a lot of anxiety disorders and depression
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
a late-shifted cortisol pulse, in particular, a 9:00 p.m. or 8:00 p.m. increase in cortisol is one of the consequences, and maybe one of the causes, of a lot of anxiety disorders and depression
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So cortisol levels are increased. In particular, there's a signature pattern of depression whereby cortisol, the stress hormone that normally is released in a healthy way only in the early part of the day is shifted to late in the day. In fact, a 9:00 PM peak in cortisol is one of the physiological signatures of depressive like states.
A late shifted increase in cortisol, however, 9:00 pm cortisol, 10:00 pm cortisol, is well known to be associated with depression and other aspects of mental health, or I should say mental illness.