Bryan Johnson· Author
But Ionescu & Frohman (2006) showed pulsatility is preserved even under continuous DAC stimulation; pulse frequency and magnitude unchanged, with a 7.5-fold increase in trough GH.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
But Ionescu & Frohman (2006) showed pulsatility is preserved even under continuous DAC stimulation; pulse frequency and magnitude unchanged, with a 7.5-fold increase in trough GH.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
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Ionescu & Frohman (2006) showed pulsatile GH secretion persists even under continuous CJC-1295 DAC stimulation; baseline increases while the daily rhythm stays intact.