Peter Attia· MD
the issue is that so in other words what's the highest what has the greatest sensitivity to Falling testosterone right so the way to cover yourself is just be in the upper cortile that's what is if I'm in the upper qu I know I'm covering because everyone's different so but again you're saying when you said 200 nanograms per decer that's total how do we determine free right and the cut offs that's important everyone's different so you know I I have to say this I never understood why we use this number 300 what are you telling me 300 nanogram is is the definition for hypogonadism so are you telling me that 290 we must all feel bad and at 310 we must all feel good that is not true right but that's what that's what it's it's it's come to so the reality is that there are many patients at lower levels that feel good it's based on the sensitivity of the antigen receptor so when I was a fellow and in my lab very beginning we would take the blood we go back and count the CAG repeats patients who had longer CAG repeats would have more sensitive receptors and why is that in sensitive receptor excuse me because everyone's different your receptors and my receptors have different sensitivities genetically how we're made so everyone has a different sensitivity of the receptor so many have shown that people respond differently to different dos is based on sensitivity