Andrew Huberman· PhD
The reason we have two sites of release is because these neuro chemicals do not cross the blood-brain barrier. And so waking up the body with adrenaline and waking up the brain are two separate, so-called parallel phenomena.
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
The reason we have two sites of release is because these neuro chemicals do not cross the blood-brain barrier. And so waking up the body with adrenaline and waking up the brain are two separate, so-called parallel phenomena.
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Cortisol can cross the blood-brain barrier because it's lipophilic. Meaning it can move through fatty tissue. And we'll get into the biology of that in another episode. But cortisol in general is released and has much longer term effects. And as I just told you, can permeate throughout the brain and body. Adrenaline has more local effects. Or at least is segregated between the brain and the body.