Arginine doses of 3-10 grams or more can increase growth hormone levels, but exceeding a threshold can blunt the effect.

“L-citrulline may actually be the better way to get arginine increases than arginine itself.”

“if one's goal is really to increase arginine in the blood for whatever reason, arginine may not actually be the best way to do that. Because of the way it's metabolized in the gut, it doesn't have access or get access to the tissues that you're most interested in in terms of increasing growth hormone or vasodilation for that matter. And in that case, there's something else called L-citrulline which has powerful effects on vasodilation, powerful effects potentially on growth hormone levels via the arginine pathway. But basically L-citrulline, it acts as sort of a donor, or it's kind of a biological prerequisite for arginine and can lead to even bigger arginine increases than you would get if you took arginine itself.”

“The amounts of arginine that people take are anywhere from three grams to 10 grams, or sometimes even more. Although, this is definitely a case of more is not better. There's a threshold at which growth hormone release is actually blunted by taking more than nine grams of arginine.”

“So what's interesting, however, is that whether or not it's by mouth or by vein, taking arginine can dramatically increase growth hormone release and the levels or the amount of increase was anywhere from 100 on the low-end but anywhere basically from 400 to 600% above baseline.”

“Arginine the amino acid arginine can increase growth hormone levels substantially the levels and the amounts of gr of arginine required to get big growth hormone release increases is pretty substantial so some people will take Arginine before bedtime some people will take it before exercise the prerequisite again is low blood glucose blood glucose is high it's going to quash the effect the amounts of arginine that people take are anywhere from 3 G to 10 gram or sometimes even more although this is definitely a case of more is not better there's a threshold at which growth hormone release is actually blunted by taking more than n grams of arginine”

“what's interesting however is that whether or not it's by mouth or by vein taking Arginine can dramatically increase growth hormone release 400 to 600% above baselines these are huge increases in growth hormone”