Paul Saladino· MD
iodine circulates in your blood and is taken up by these thyroid follicular epithelial cells and really is moving across those follicular epithelial cells into the um essentially a different part of the thyroid gland where it is combined with thyroglobulin thyroglobulin if people have hashimoto's el mentioned hashimoto's which is an autoimmune thyroid condition in which there are antibodies to a few things in the thyroid one of them is thyroglobulin so if you generate antibodies to thyroglobulin sometimes we think of that is that an autoimmune thyroiditis is that hashimoto's and you see these iodines combine on thyroglobulin they make mono-iodo tyrosine diiototyrosine up here and there is coupling of the mono and diiototyrosines by thyroid peroxidase right and then there are t4s and a little bit of t3 on this thyroid globulin and they are then cleaved and the t4 and t3 are excreted from the thyroid