Mouse models of neurogenetic syndromes with social impairment show reduced oxytocin levels in the hypothalamus.

“there's been m a handful of small studies where there has been some you know there's been some benefit Maybe no benefit Small effects we did a study that was a small study at Stamford and it was based on um Mouse genetic data and I'll I'll sort of walk you through what we did um so there's multiple Mouse models of these neurogenetic syndromes where um people have social impairment right we can Qui quibble about whether that's autism or not but that they have social impairment and so that there are this um fragile X Mouse there's a PR willly syndrome Mouse which is the magile 2 Gene that um gets manipulated and then there's a catnap two mouse and in all of those instances when you genetically modify those mice you see a reduction of oxytocin in the hypothalamus”

“what's really cool is you can give oxytocin across development in those models and at least in the cat to Mouse you can restore oxytocin neuron number to equivalent of control animals suggesting that oxytocin is doing something in these oxytocin deficient animals”