The neural pathway for the stress response moves from the prefrontal cortex to the hypothalamus, then to the brain stem, and finally to the periphery.

“we're moving from the prefrontal cortex to the hypothalamus then to the brain stem and then from the brain stem out to what we call the periphery to the body to the spinal cord to the blood vessels themselves to the organs of the body like the gut and the heart and the lungs”