Andrew Huberman· PhD
In fact, a lot of the effects of growth hormone are mediated by its effects on the liver. So growth hormone is released, goes to the liver, and then the liver releases something called IGF-1, insulin growth factor 1.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
In fact, a lot of the effects of growth hormone are mediated by its effects on the liver. So growth hormone is released, goes to the liver, and then the liver releases something called IGF-1, insulin growth factor 1.
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the i the one way we explain this to patients is igf-1 is the integral of growth hormone so if you want to get a sense of how much growth hormone is floating around to a first-order approximation you get a sense of how much igf somebody has you get a sense of how much igf is being produced by the liver and to your point that's all systemic or what we would really think of as an endogen an endocrine igf
we know that growth hormone increases the liver production of igf-1 and igf-1 has always been thought of as kind of like the master hormone that is increasing muscle mass
but it has a specific action of binding to its receptor in liver and releasing the second important growth hormone which is called igf-1 it stands for insulin growth factor one and and so those are the hormones that we're talking about the advantage of igf-1 is that it's measurable growth hormone is measurable in provocation and in young people and not much in old people so igf is kind of the biomarker for this action
as it declines you have this decrease in inhibitory feedback that then tells your body okay now that igf-1 is not present in significant quantities it's okay to you know release GH again