Mechanical and chemical information from organs provide details about gut fullness, heart rate, gut balance, and the presence of pathogens.

“There are two fundamental features of what's going on in your body that need to be communicated to your brain, these neurons in your brain stem in order for your brain and your body to work together correctly. And the two types of information are mechanical information. So things like pressure, things like lack of pressure and chemical information, whether or not your gut is acidic or whether or not it's not acidic, whether or not you have some sort of pathogen, you know, something that you ate or that got into your body somehow and is making you sick or whether or not you don't have a pathogen in your body.”