Bryan Johnson· Author
While VEGF function and signaling are known to decline with age, serum VEGF levels do not exhibit a clear age-dependent decline.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
While VEGF function and signaling are known to decline with age, serum VEGF levels do not exhibit a clear age-dependent decline.
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A study of 80 healthy adults, aged 20 to 80, reported serum VEGF levels between 62 and 707 pg/mL, with an average of 160 pg/mL (145 pg/mL in men and 177 pg/mL in women).