Andrew Huberman· PhD
so it's this enzyme that's produced by three bacteria in particular in the gut and I see a lot of men and women who have elevated beta glucuronidase and then they have some estrogen dominance related to that
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
so it's this enzyme that's produced by three bacteria in particular in the gut and I see a lot of men and women who have elevated beta glucuronidase and then they have some estrogen dominance related to that
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beta glucuronidase in the gut so we see in Phase three basically detoxification of estrogen we see increase in you know beta glucuronidase that estrogen gets re you know enterohepatic circulation and these women who have this estrogen dominance like if their gut is broken it's even just more vicious cycle
then the third phase is actually um in the colon and something called um beta glucuronidase essentially um if you have high enzyme activity it can actually unpackage estrogen and cause recycling which for somebody who is you know estrogen dominant this is a real issue if you're reabsorbing your estrogen and continually recycling it
Now, you have a buildup of estrogen, so you have women with estrogen dominance. They have bad periods and PMS and breast tenderness and that's all because of that pathway.