Sublingual estradiol may be a cheaper and potentially lower-dose alternative to other forms of estrogen administration, but lacks robust clinical data.

“So I think it's fascinating. I don't have many patients on it, but I would love to see data sort of look in that direction because it's cheap. Oral estrogen is cheap. Uh you get lots of doses. You can dose it. You know, does that mean you can get away with a lower dose? You can get away with a lower dose. Absolutely. You must, right? Because of that first pass effect.”