Opioids reduce testosterone and estrogen by disrupting GnRH neuron receptors in the hypothalamus. — Whalespan
Opioids reduce testosterone and estrogen by disrupting GnRH neuron receptors in the hypothalamus.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“excessive opioids are very problematic for sex steroid hormones, I don't think anyone will have any trouble finding any literature on that, you can just go into PubMed, you can put opioids, testosterone, or opioids, estrogen, but the major effect is actually way up in the hypothalamus to shut down the production of GnRH, the very hormone that stimulates testosterone and estrogen release”
“the opioids dramatically reduce levels of testosterone and estrogen and they do that mainly by disrupting The receptors on gonadotropin releasing hormone neurons”
“in fact people that take large amounts of opioids or even take low levels of opioids for long periods of time will develop all sorts of endocrine syndromes that's been shown over and over again gyacom Masia or male breast development in males disruptions to the ovary in females”