Bryan Johnson· Author
Five days post-dose, my morning cortisol levels had dropped by 42%, and DHEA-S (a marker of adrenal activity) also dropped by 45%, aligning with inhibited HPA-axis and adrenal activity.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Five days post-dose, my morning cortisol levels had dropped by 42%, and DHEA-S (a marker of adrenal activity) also dropped by 45%, aligning with inhibited HPA-axis and adrenal activity.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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