Repeated exposure to high magnitude chemically induced dopamine peaks leads to habituation and increased pain perception.

“What happens is when you have a big increase in dopamine, you also will get a big increase in the circuits that underlie our sense of disappointment and re adjusting the balance. And with repeated exposure to high levels of dopamine, not naturally occurring wonderful events, but really high chemically induced peaks in dopamine. High magnitude, chemically induced peaks in dopamine. What happens is those peaks in dopamine start to go down and down and down in response to the same, what ought to be incredible experience. We start to what's called habituate or attenuate, and yet the pain increases in size.”