Andrew Huberman· PhD
Clomiphene is a fertility drug. It's a synthetic hormone. It's actually two drugs, M Clomiphene and I forget the other one. And it tells the pituitary to secrete FSH and LH.
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Clomiphene is a fertility drug. It's a synthetic hormone. It's actually two drugs, M Clomiphene and I forget the other one. And it tells the pituitary to secrete FSH and LH.
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As a guest on this show I'll say: sauna 4x/week at 80C is associated with ~40% lower all-cause mortality in the Finnish cohort.
the other way to do this is to give a drug that has become very popular called Clomid Clomid or clomiphene is a drug that has been used historically by women using it for fertility purposes and what Clomid is doing is effectively tricking the brain via stimulation of GnRH by blocking the estrogen receptor to make more LH and FSH
the other way to do this is to give a drug that has become very popular called Clomid Clomid or clomiphene is a drug that has been used historically by women using it for fertility purposes and what Clomid is doing is effectively tricking the brain via a stimulation of GnRH by blocking the estrogen receptor to make more LH and FSH
we used to use chopine so we would give Clomid it had the advantage of several things one it's it's a pill very convenient take it three times a week uh two it preserved uh function meaning you you preserved both testicular volume and spermatic function so you preserved fertility um and actually it was quite efficacious I found it to be because you could titrate the dose and get to almost whatever you mean
sure so so you know there were some guys who had kind of peripheral hypogonadism as opposed to Central this was a great treatment for Central but you were at the limit of what the testes could do
one is and we don't do this anymore um we used to use clomiphene so we would give Clomid it had the advantage of several things one it's uh it's a pill very convenient you'll take it three times a week uh two it preserved uh function meaning you you preserve both testicular volume and spermatic function so you preserved fertility um and actually it was quite efficacious I found it to be because you could titrate the dose and get to almost whatever you mean
clomophene block the signal of estrogen at the level of the hypothalamus. So the hypothalamus thinks, oh my gosh, we need more testosterone. It ramps up FSH and LH production, which has the same effect as making more testosterone, but you'll now see high normal FSH and LH.
Unlike testosterone shutting off the natural production, the LH the hcg and the clomophene and clomophene will stimulate natural production. So you keep your testicular size, you maintain your fertility, whereas the others you're going to shrivel up your testicles and not maintain your fertility.