Andrew Huberman· PhD
Cortisol can cross the blood-brain barrier because it's lipophilic. Meaning it can move through fatty tissue. And we'll get into the biology of that in another episode. But cortisol in general is released and has much longer term effects. And as I just told you, can permeate throughout the brain and body. Adrenaline has more local effects. Or at least is segregated between the brain and the body.