Andrew Huberman· PhD
Epinephrine cannot, epinephrine is polarized, the shape of it is such that it can't make it through the blood brain barrier. That's one of the reasons why it's released both from the adrenals in your body and released from this brainstem area, the locus coeruleus in your brain. That's a powerful thing, because what it means is that the body can enter states of readiness and alertness while the mind remains calm.